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Here's your problem.
What doesnt work is disabling mods mid-game, the (vaulty) information is already baked in your save...just saying
Things like bit defender can block the game from having access to the folder Documents\My Games\Fallout4 where it writes the needed information.
As for crashing while playing removing mods midgame or having conflicting mods can cause this.
Also there is a certain GPU that needs the weapons debris turned off in settings or you can get random crashes.
That said: a) it's doesnt proof much. game might crash in another location and b) if you want to continue, do at your own risk. As I said, you cant get rid of mods, apart from texture replacers.
at the very least a folder other than "program files" that most programs select as default during install pretty much anything installed there in windows 10 takes administrative privlages to write to the disk.