About to start The Molecular Level SPOILERS

[Smokin Kippers]

I’ve done all available main missions for the Brotherhood and the Railway at this point and now they only offer raidiant quests. If I get the Minutemen to build the teleporter will I turn either of them hostile if I plan on taking down the Institute? I don’t really care about the Railway but I’d ideally like to keep them alive

[EolSunder]

nope they won't turn hostile unless you attack them. If your playing the minutemen its fine with the brotherhood and railroad they won't turn hostile.

What i like to do is after you take down the Institute, turn against the brotherhood also (game is basically over anyway) see if you can get them to attack the Castle also lol.

[Smokin Kippers]

Will it lock me out of the Brotherhood quests? Like what happens with Danse? It’s been a while but the last time I did the Brotherhood ending I think they give you the task to scan the Institute as part of the Molecular Level and that’s how you descover his secret?

[EolSunder]

If you take down the Institute i believe all it will affect is any institute-linked quests, you an still do other radiant quests and faction-only quests which have nothing to do with the institute. I personally do the faction quests before the final faction ending, but i think you can still do the other friendly faction stuff if you haven't made enemies with them, like with Danse.

Depending on which factions are enemies (you can play the minutemen and only make enemies of the institute), you'll lose 1 companion per enemy faction. Danse with brotherhood, XJ if enemies of the institute, and Deacon if enemies with the Railroad.

For me, at the end of the game its just do what you want time anyway since i do the final faction quests near the end, no need really to just keep playing i finish and reroll a different build to have some variety. Some like to build neat settlements, i don't i only use them for basic needs, i don't have any inclination at all to play a SIM game where i sit on a pretty porch and look out over the river from my cool real-life settlement, you get the idea.

[Stardustfire]

Each of the Factions has Quests in there lineup that makes one of the other Factions Hostile, but u get a big fat warning if that will happen and u will be asked if u want to start teh quest anyway.

U can get a hilarious setup with tons of good loot because most of the factions dont like each other: When u reach the fight for bunker hill just inform BoS and Railroad together, this ends in Institute Forces, BoS and Railroad fighting each other, and a lot of good loot will remain. Railroad brings tons of gauss rifles and ballistic weave armor tto the dance, Bos brings its BoS Stuff and on Institute side u can grab some institute weapons for disssemble and even some runner stuff when u execute them.

[EolSunder]

not a secret you don't need to block it out, game has been out for years. And you don't need to inform either, they are already at the fight no matter what, informing or not-informing them makes no difference. That is a nice fight because you can blast all of them and grab all their loot without a problem.

Just don't bring a faction companion who will get mad (like Danse will get mad if you start killing BOS troops, Deacon with the Railroad, etc), and don't kill any of the npcs who YOU Can kill but the fighting troops cannot. You don't want to accidently kill Trashcan Carla who hangs out there a lot, or Kessler who you need to give you the settlement after the fight, etc. Just kill the fighting troops. Lots of them about, and lots of goodies to collect after.