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You can join and work with every single group, but at one point it becomes one group OR The Institute. The Mass Fusion quest makes you either Railroad/Institute/Minutemen or Minutemen/Brotherhood. Whichever one you choose, those are the only options you'll have for the endgame. I think it's RR/Institute. Can't remember where the breakoff point is for those two questlines as far as the Institute side of things goes.
You can always finish the game with the Minutemen. They are the Yes Man of FO4. Not sure with Nuka World if you can get locked out of the MM, but I think if you go back and kill everyone to do that quest, Preston will be your buddy again.
There is an ending of sorts where you will have the Railroad, Brotherhood, and Minutemen still alive and kicking AND willing to give you all their radiants. It's a semi-complicated thing but there's walkthroughs and such on YouTube for that ending. You end up finishing the game with the MM on that one, but the other two Factions are your friends as well.
Ultimately, each faction will try to eliminate two other factions:
Brotherhood: Destroy Institute and Railroad.
Institute: Destroy Brotherhood and Railroad.
Minutemen: Destroy Brotherhood and Institute.
Railroad: Destroy Brotherhood and Institute.
The Minutemen may not require you to destroy the Brotherhood until there's actual hostility between them, but it remains the final stopping point at which everything is resolved as far as possible.
Only if you aggro them will they ever initiate the Defend The Castle quest.
You can also join all 4 groups if you use a ♥♥♥♥♥♥♥ of console.
You can also just say to heck with the main storyline and refuse to follow through on the Blind Betrayal or Mass Fusion quests. Stopping on both of these will put a halt to all progress of the main story (unless you deliberately attack a faction), since other quests depend on them, or on quests after them.
I don't remember Blind Betrayal or Mass Fusion being active specifically stopping you from getting regular radiant quests.
No more radiant quests? WHERE DO I SIGN UP! ;)
The #1 reason I wanted, and refuse to play without, an alternate start mod. I hate having unfinished quests in my lists, and any mention of Concord for the first 20 hours or so of a playthrough makes me cringe. Gotta get that Perception Bobblehead though, so it will eventually happen.
If you are working with the MM, and plan on staying with them, you can wipe out the RR as soon as you meet them (you can do the courser chip yourself), you can inititate hostilities with the BoS and then do Defend the Castle later on, and then the Nuclear Option with the MM to wipe out the Institute. The only faction you can't wipe out permanantly is the Minutemen. Even so, you'll still get randoms with the survivors of whatver Factions you destroy.