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Alternatively, either make sure you kill them in one, hit and run so you don't get found, use a VATS crit to shoot down the nuke before it gets near (unlikely but can be done sometimes), or abuse VATS magic damage resistance during the firing sequence to tank it.
JET is your ONLY ANSWER for direct combat.
if you cant fight them direct run away
or use POWER ARMOR - upgrade with more dr
or sneak around..............tough but doable
Step 1) Skulk around until you hear/see/smell enemy with Fat Man launcher.
Step 2) Stealthboy.
Step 3) Position yourself directly adjacent to enemy's rear end - preferably between the cheeks if at all possible.
Step 4) Consume Jet and Psycho, or PsychoJet.
Step 5) Unload everything you've got directly up into enemy's cranium.
Step 6) Skulk away.
...^this.
Side Note, Power armor won't stop you from getting exploderededed by a fatman anyway, if anything, it's worse because it increase your hitbox size which might make some objects that provide cover against the blast ineffective.
Also, knowing where Fatman-wielding enemies are is helpful.
1. Lexington Square, inside the makeshift skybridge over the town square.
2. Outpost Zimonja
3. Gunner's Plaza, Gunner Captain+ that overlooks the pavillion and marshlands (EXTREME DANGER: Respawns in less than 72game hours, even on Survival)
4. Quincy, on top of the Church
Also I'm playing in survival mode, sometimes vats freeze so I rarely use it.
Not mention clearly in op:
I'm using gauss rifle in about 200 range... and I'm been found then try to flee but failed.
Most time I died form those fatman/ missile launcher ...are those legendary enemy.
scattered in their outpost or just in random encounters.
Don't know is luck or bad luck XD