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Edit: Of course, scripted mods are a whole new bag of mischief so that's not gonna work.
heh - had yours become unavailable in-game, too? The game does sometimes renumber it! :D
Edit: That's a tad misleading. The game doesn't renumber your save. It generates a new number for your new save, sometimes, I've noticed. Probably when LO changes?
Well, to start with - no. If your game has mods activated then changing them around or removing them is bad no matter when you do it.
But you shouldn't be installing mods until you've exited the vault. Start a clean game with no mods installed until you are standing on the platform outside the vault. Save there and start modding.
Yeah, that REALLY helps with play-testing, not!
I guess, more to the point, none of us should endorse it. Whether it's a chance worth taking depends in part on which mods you've installed, but if anything is scripted, I'd certainly recommend just doing the intro over.
Also, unless specifically stated otherwise, it's generally best to not run scripted mods during the intro. That's when the game sets itself up, and it's best not to let anything disrupt that process.
At the end of the day, the game has no mechanism for removing assets or scripts that belong to deactivated mods from the save file. It assumes that the necessary plugins and assets exist. Removed mods can cause more benign quirks (like missing textures), it can performance issues or semi game breaking bugs if the scripting engine gets full of orphaned scripts stealing all the CPU time (scripts may be delayed, or they may fail to run entirely, usually noticed as quests becoming impossible to progress/complete), or it can cause unfixable CTD issues.
So the rule of thumb is to always revert to a save from before the mod was installed when removing it.
Edit: I suppose I ought to add, When I'm done play-testing, and altering my load out and LO, I do actually restart from the very beginning of the game. I still leave all my mods active, though. Never had any issues with my game - apart from the Cabot House quest which most folk seem to have had issues with at some point. I even mod cells I've never visited, on the fly, during my play-through's. It's knowing what you're editing or changing that matters. :D