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1- Create a desktop short cut to start the game, when starting, right click to "run as administrator", I found this very useful in Windows 10 especially.
2-Create an exception in your AV program for both FO4 and Steam, so at least you can eliminate your AV as a culprit. Some AV programs can prevent FO4 from starting.
Another question would be, are you running the base game, or are you running a game that's modded?
If this alone doesn't fix it for you, I've also updated DirectX and I have run as administrator also checked. Hopefully, one of those things or a combination does the trick for you.