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Nope being dumped in a vat of fev is pretty much what you need for super mutants the only special qualification put out in 1 is that you need uncontaminated people due to the rupture of the west tek fev vat causing resistance to the effects in the surface population. And that only if you want to reliably make smart mutants not for super mutants in general.
The Master did experiment (with varying results), but FEV tends to produce super mutants more reliably than anything else because enhancing humans was the reason it was created in the first place.
The Institute doesn't have a cure for cancer, and Shaun's few seconds of exposure were probably far less damaging to his DNA than someone living their entire life in a radioactive wasteland.
Gen 2s all it took was enclave slaves digging out the base without protective gear getting exposed to turn theu didnt even get dipped and they sure as hell desides frank didnt have any experiments done to them