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Just checked your profile. Try disabling any mods that change game play in anyway. Not settlement building mods.
As for disabling mods, I did so (removing them completely from my session). I then went out and tried to die again. Same result: I die, the game loads for a couple seconds, and then boots me back to the start screen with all my progress lost.
Can click the game properties and check the box to run it as administrator from Steam should resolve that.
EDIT I checked to see if the comp was doing this for all games. Seems like it's just Fallout 4. I checked some progress I've made on Rocket League and it's all still there.
You say "modless". Just disabling your mods may not be enough. Also, uninstalling some mods does not remove all of it's files from the game folder. I can only suggest you re-install the game.
If you still have any mods installed, uninstall them first then uninstall the game. Next go to the game folder located in C:/Program Files[x86]/Steam/steamapps/common/Fallout 4 and delete anything remaining in the game folder then delete the folder it'self. Now go to Documents/My Games/Fallout 4 and delete the Fallout4.ini and the Fallout4Prefs.ini if they're still there. Then re-install the game. You have a fresh clean install and saving has got to work again.
Edit; Go to Documents/My Games/Fallout 4, right click on the saves folder and make sure it is set to Read Only.
This next generation update is sure to have broke some mods and the Script extender. You may have to wait a few days for F4SE and your mods to get updated. Then, download those updates. Until then, I'll assume your saves are toast.