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The first Progenitorial Wrath will preferentially target a Sentinel first, then a Medic, then your party leader. It happens after 5 or 6 of Orphan's attacks, so when you know it's coming you can shift to a paradigm where you have a Medic or Sentinel (NOT your leader) and guarantee that it does not cause a game over even if the instant death succeeds. Later Progenitorial Wraths target randomly even if a Sentinel is on the field. Ideally, you should kill Orphan before it has time to use Progenitorial Wrath a second time; this is very doable with a good strategy for damage output. If you do see a 2nd Progenitorial Wrath, you can 100% save yourself by Summoning.
Thus, this battle is all about strategy and execution, not luck.
Several parties can work well against Orphan; what's more important is ability access. Ideally, you want access to Curasa, Curaja, Deprotect, Deshell, Imperil, Poison, Slow, Bravery, Faith, Enfire (or any other En-spell), Haste, Protect, Shell, and Veil, although you certainly don't need that entire list in order to succeed.
Note that both Merciless Judgment and Progenitorial Wrath can happen regardless of whether or not you have Orphan staggered. In fact, one Merciless Judgment is highly likely to happen during stagger since it is triggered when you drop Orphan below 40% HP.
Generally your guide follows my basic motto, setup for high damage output and kill the enemy before he kills you.
So as you said in this fight enbuffing will be a very high priority, alongside the appropriate debuffs, and then kill him as fast as possible. An alternate to staggering is attacking him with coms when he is 80-90% towards stagger so just maintaining the highish chain multiplier.
Heal when you need it.
I used 3 paradigms:
sab/sab/syn - poison + slow
med/sen/med - Judgement attack
rav/com/rav - stagger
My party is Fang (leader), Hope and Lightning. I normally have Sprint Shoes on all three but replaced Fang's with a Cherub Crown (to counter instant Death).
Paradigms:
Com / Rav / Rav for stagger.
Com / Rav / Com for nuking once staggered.
Com / Med / Med for quick recovery and heals after Judgement / Poison / whatever hi-dmg.
Sab / Syn / Med for debuffing and buffing party while healing.
Threw a Librascope, started to debuff, then stagger, then nuke.
Everytime I saw Orphan cast Judgement I stopped what I was doing (even when he's staggered) and switched to Com / Med / Med. I got fully green HP within 2 seconds after hit by Judgement.
Back to stagger or nuke, pretty easy.