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This is a stackable debuff which might have a different effect each time it is added, one among those might decrease your overall hp.
To get rid of simply rest at a site of grace.
In the vanilla game, some great runes grant you more hp but get deactivated whenever you die. To reactivate them, go into your inventory and activate an item called Rune Arc. If I'm not mistaken you even get a small hp boost just by activating it without having any great rune equipped.