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https://youtu.be/iLCIFe9h6zc
this guy tests this talisman at the end of this video, you might want to watch it
Wait tll you level up (Vig) and find better talismans and armor...you can easily get 50 - 60 physical with all types of buffs and even higher elemental.
That's a difference of nearly 60 damage negation! Just over 1hp per point of negation. So basically it's negligible throughout the entire game until I have insanely high negation from end-game armor that sacrifices all mobility, especially when for most of the game I've been dealing in only increments of 2 or 3 points. I'm better off with a bigger health pool and/or not getting hit.
You're simply not meant to stand there and take 5+ hits from enemies appropriate to your level.
The Soreseals/Scarseals are BASICALLY worth it if you get a percentually greater HP boost than the amount of damage negation you lose, but keep in mind that the effect is much more noticeable with bosses than trash mobs.