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ares is the inverse of dionysis rewarding things that are used sparingly.
that said, both gods can run cast builds that are really good.
i usually use one of the two to fill out my cast or call options if the weapon isn't very good at applying their effects.
as far as hangover specifically is concerned, you usually want to go for the aphro duo boon if you are actually trying to use hangover. i have won a bunch of drunken fist and hangover gun builds on various heat levels. hangover is definitely a niche, but they work well on certain things.
But usually Dio ends up being the "junk buffs third guy", and I pick Nectar gives +25hp and the Fountain gives +4% attack boons.
I'd guess it could works with the shield, but I didn't played much with it yet. At least it works well with the bow for me so far, I barely took any damage with a build based on his DoT during the game I did before with deme/dio mainly
But since it only stacks up to 5 times, if you just sit there and pound away, you'll max it out pretty fast. So it works best with tactics where you duck in, hit a few times, and then dash away for a few seconds. (Possibly attacking a different enemy in the meantime, or reloading.)
Hangover also scales great with pomegranates. Most boons have sharply diminishing returns as you add more poms, but hangover never gains less than +1 damage/tick/level. One run I got my drunken strike up to level 10 so it was dealing something like 14 damage/tick (104 damage per stack across its full duration).
Hangover also benefits more than other boons from global damage multipliers due to the stacking rules. If your attack deals 20 base damage, then +100% attack from a boon and +50% global damage adds up to 50 damage (20 * (1 + 1 + .5)). If you replace that +100% attack with 20 hangover damage, you'd do the same damage without the global +50% bonus, but with the global bonus you're now dealing 60 damage (up from 50), because the global damage modifier will multiply with the hangover instead of adding to it.
And the Dionysus/Ares duo boon makes hangover better by nearly +50%, multiplying with all other bonuses.
In terms of other Dionysus boons, I like Positive Outlook (damage reduction when below 40% health, which applies to more like 2/3 of your effective health bar due to the revive mechanics). Premium Vintage can be circumstantially good (+max health per nectar). If using hangover, Numbing Sensation is handy (hangover also reduces move speed).
His cast has several neat advantages, but also several disadvantages compared to other casts. (High damage, big AoE, stunning against unarmored enemies, good combo boons...long travel time, no homing, no Boiling Blood/Abyssal Blood benefit, bloodstones can't be recovered quickly even if you miss or the enemy dies.)
but for dmg i prefer artemis/x or ares/x combos
It's actually a bit of a fallacy that Ares wants you to hit with things that are used sparingly. Ares adds the most damage with a weapon that will hit again as soon as Doom finishes, so it actually tends to do more damage with weapons that hit often. The thing you want to weigh is Ares vs other options. Ares is best when it compares favorably to %-based boons and to Zeus, so weapons that have poor natural DPS like the spear attack/special or shield special favor Doom, while a weapon like Aspect of Arthur wants a %-based boon even though it hits infrequently, and Rail basic attacks would prefer Zeus even though they don't have great DPS.
Also, Merciful End is a thing, and generally that's best when you put Athena on both special (to get the duo boon offered) and dash (to proc it), and Merciful End is freaking nuts on fast weapons with good dash attacks, so consider that as well when you're taking Doom.
Dio legendary is freaking amazing and 100% makes hangover worthwhile, especially if you get Ice Wine with it. The two hangover duos are both very good too. You can lean into scaling it, and it will remain relevant all run, as long as you're able to stack it sufficiently.
Use a weapon attack/special that can hit rapidly like the railgun attack or bow special. Get hangover asap using the keepsake and fated persuasion if you have to. Throughout the rest of the run, get poms when you can and feed them to your hangover. Get an Aphrodite attack/special/cast/dash/call boon as quickly as you can and then keep taking Dionysus/Aphrodite to get the duo boon that allows hangover to stack to 8 on enemies with the weakness debuff.
Weakness and hangover will become the main thrust of the build, so pick up as many boons from those gods as you can (extra damage, longer duration, reduced damage from enemies, reduced movement speed, etc).
Keep getting poms to increase the level of hangover further. If you get a chance to increase its rarity through Eurydice or a Demeter boon, do so. Ares also has a powerful duo that makes hangover deal damage 3 times per second instead of 2, but I have found that one to be rare.
With a decent set of boons and enough poms, hangover does a very respectable amount of dps. My best results are with Charon aspect bow.
His Support Boons are quite Helpful if you are having HP Trouble like The 30-40% of you max hp gets refilled each room, or Fountains Refill max hp and a Damage buff 3-5% each drink, so thats good, Better Early On but can still be helpful because of Styx's Fountain
His Duos are also Great, but Dio is a Hit or Miss, I Love him when i get a support item, hate him with a Hangover. but he has his Place in my heart.
"Zag my man"