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https://steamcommunity.com/sharedfiles/filedetails/?id=2175591198
Or that guy?
https://steamcommunity.com/sharedfiles/filedetails/?id=2177250924
Against hundreds of enemies spawning every second, you need reliable AoE. Either a sweep unit that you upgrade with quick, or a good bunch of targeted spells, and some with holdover.
The best remedy against sap is simply not to use units with low attack. You can use rage to outscale the sap, or abuse whatever mechanic such as gorge, incant, slay, harvest, reform, etc to increase your attack. Or you can build an awoken tank and use adaptive mutation to turn it into a high dmg unit. Melting also have that spell that remove all debuffs. Alternatively just stack up spell weakness and kill him with one final high damage spell.
There are many ways to deal with this guy and you know from the beginning which final boss you are going to fight, so it's really a matter of knowing how to prepare yourself.
If you don't know, in addition to the listed traits for Seraph's effect each turn, each fight has the following:
Temperant: Shadewings, which are backliners that do 15x2 damage and have 5 HP (and get even stronger on slay; between that and multistrike, chump blocking isn't effective) appear in most waves, and there are two of them in waves 2 and 3.
Chaste: Pyrewings, which have sweep, emberdrain and 4 / 150 stats appear in waves 2, 4, and 6. If you set up on multiple floors and cannot kill them before they attack, silence them, or drop them to 0 attack, you can end up having 0 ember on several turns of the fight.
Dilligent: Purifiers (2 / 10 stats, give a Weight of Contrition after combat) appear on turns 1, 2, 3, 5, and 7, and will slow you to a crawl if you set up top or can't kill them. Additionally, your deck starts with three blights in it that cost 1 energy and do 1 pyre damage if unplayed. (These do not count for Abandoned Stave for some reason, but do trigger Ember Stasis and power up Dante). Additionally, the fight has an unusually high number of Gilded Wings.
But yeah, the sap itself is largely ignorable if you have anything that gains rage or attack every turn. It also has no effect on thorns, frostbite, spell weakness, or spell damage, and never hits the Pyre to reduce the effects of Vapor Funnel or Siren's Song as methods of clearing. You just have to watch out for situations where units hit 0 attack and stop triggering Strike effects or being able to kill Shadewings.
https://steamcommunity.com/sharedfiles/filedetails/?id=2178073326
Both the non-cleansing Seraphs are notoriously straightforward to stack frostburn on due to the high amount of waves, so if you're having trouble I'd suggest starting with Stygian main.