The missile in the game only has a very limited flight time: after 5-10 seconds it just disappears if it doesn't hit a target. This is problematic because it means you can't taget something very far away. The problem here is that you are always very close to the threshold of being killed by your nuke when you use it.

My suggestion would be to at least double the flight time of the missle. This doesn't mean that the missile should have more thrust, just that it should be able to fly through the air for longer, before disappearing.