I use Frackin Universe, Datebound, RPG Growth, NPC Spawner+, Crew Customization+, Smart Crew and a ton of other mods. Seems to be working well enough with everythng. That being said I gladly take bug reports and I will see if I can do something about it.

Frackin' Universe: All changes should work with FU's crew members. If you spot one that doesn't, please let me know, they are a lot.

Datebound: The Datebound "Partner" role is fully integrated in this mod with permission from Audie, the creator. It is the crwemembersobff (Partner) role as usual. You do not need the original DateBound, however if you are subscribed to it, you do not need to unsubscribe (and you probably shouldn't since it is unlisted and you will probably have trouble finding it again). My mod will overwrite it without any issues. Here we now have subtypes with the chemist skills instead of the heal.Denoted by the roles:
Partner(Medic) - Original
Partner(Hiker) - Jump boost (Blue)
Partner(Athelete) - Speed boost (Green)
Partner(Brawler) - Damage boost (Orange)
Partner(Explorer) - Light (Yellow)

Crew Member Buff: Everything should work fine, with the exception of the skill activation cooldown, that mod reduces it to 10 seconds, but I had to route the activation logic to somewhere else, so their change will have no efffect. Also, this mod reduces the teleport range significantly. This means that if you send your follower to operate a device or attack a target far away, they might teleport back before reaching it, or while fighting it.

Earth's Finest: Should work fine. Caveat: It allows more than 2 followers. This mod will always address the first follower with click, and the second follower with Shift+Click, any additional followers will follow you in the vanilla way (only respond to "E" interactions for follow and wait). HOWEVER! I do not know for certain if the game loads your companions in the same order every time, this means that maybe at any moment the game could switch them around and you would be controlling a different pair of your companions. This is something I might confirm and address later.

Smart Crew: I use it. And I have been told by others that use it that they work well together.

Supper's Combat Overhaul: Can be used together but issues exist. At the very least I noticed that it creates some ghost entities on top of NPCs which complicates selecting them with the commanding hand. It prevents you from using companion skills. I don't have the time/energy/willingness to dive into their code and see what's the deal. That mod does a lot of weird things. I suggest you use the "behaviors only" version: https://steamcommunity.com/sharedfiles/filedetails/?id=2596021740

Be warned that removing SCO from an existing universe will probably destroy it.