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[More Pain Genes] PatchOperationReplace … failed
[More Psychic Sensitivity Genes] PatchOperationReplace … failed
[More Study Genes] … failed
[More Toughness Genes] … failed
[More UV Sensitivity Genes] … failed
These patches are written against Alpha Genes 1.4 / vanilla Biotech genes pre‑1.5.
RimWorld 1.5 changed gene XML structure (new tags, reordered lists). The patches can no longer find the nodes they expect, so they fail and later throw null‑reference errors (nullifyingGenes list later in the log).
Fix
Remove the individual “More … Genes” addons – all of their content is now part of Alpha Genes itself.
Or update to the 1.5‑ready versions if the author has released them (check Steam Workshop changelog).