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Depression Quest?
The Cat Lady: depression/suicide.
Downfall: Halluzinations.
The Black Mirror: Schizophrenia.
Gabriel Knight 1: Chronic Nightmares.
Max Payne 3: Alcoholic, drug addiction (didn't play it though saw a walkthrough)
I am sure there are plenty of playable characters who are soziopathic(Manhunt, GTA) or have god complex (Duke Nukem lol)...
Alice: Madness Returns
Sanitarium
I Have No Mouth and I Must Scream
Persona series
Silent Hill series
Likewise, Naked Snake's struggle to come to terms with his betrayals was a big aspect of Peace Walker.