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Their bite is stabbing so spicy safety help to reduce a lot the damages. If it has the big buff from eating her lil spiders, you can't really attacks as she's damn fast.
Try to quickly kill her small spidey before she has the time to eat one, else you better to block/parry and pray you manage to withstand the duration of her buff.
When possible, try to also wait until they're walking away from you in their lair so you can run up and land the first attack.
In essence, they are a dps check. The longer the fight drags out the higher your chances of being killed. You need to bring them down quickly with a heavy, fast weapon (ideally the Acid Edge) while parrying what you can in order to survive and healing through the attacks that you can't parry. Unfortunately, depending on your difficulty, there may be a lot of deaths trying to bring one down.
I don't think your Widow Dagger is near good enough for them. Not only less damage per hit but, as far as I remember, Widows either resist or are immune to the poison taking away most of the benefits the dagger would give you. I wouldn't go anything less than an Antlion Greatsword but really you probably need to just go after the Acid Edge before you seriously farm them.
https://www.youtube.com/watch?v=d-RKJAZ-_Zo
Granted this is on Whoa difficulty but even still it was about 7 or 8 tries for me to get this footage without dying.
Their 5 hit combo is flat out impossible to parry all 5 hits when they are speed buffed so while you are correct it also ultimately impossible and practice doesn't really fix that. Also Mithradatism does actually help with Widows. They inflict venom but when venom is on you all their attacks also inflict poison (according to wiki). I had your same view before someone else pointed that out to me in another thread.
the tick macahuitl with sour upgrades, (small amount of healing)
fire ant shield, (good block bar and chance to debuff them)
blademaster, (debuffs their direct damage but not venom)
spicy safety, (resistance to stabbing damage)
and sleek ladybird armour (extra regen)
And a bunch of beefy smoothies/granola for extra healing when needed
Club of the Mother Demon Lv9 Sour
Roly Poly Helmet Lv9 Sleek
Roly Poly Breastplate Lv9 Sleek
Roly Poly Legplates Lv9 Sleek
Any advice on trinkets? I have the following to choose from. Still trying to find the rest.
Biomedical Badge
Compliance Badge
Defense Badge
Entomologist Badge
Intern Badge
Toxicology Badge
Sarah's Charm
Thor's Pandant
Astonishing Acid
Nifty Needle
Sturdy Shell
Giddy Goop
Insulating Larva Spike
Fancy Fletching
Broodmother Trinket
Spectacular Spicy Shard
Shiny Salt Crystal
Suspicious Mint
Deuces Sign
Power Droplet
Rotten Berry Charm
Shield Solidifier
As far as healing goes, I usually carry a stack of bandages, some Beefy Soothing Syrup and on the way to the fight I use my Spicy Termite Axe to roast as many aphids as I can fit into my inventory to eat during the fight for quick heals.
My mutations were all pretty standard ones - Fresh Defense, Spicy Safety, Cardio Fan, which I use generally. Mithridatism which seems like it's negated by her venom debuff but I put on anyway since I saw some video or something that showed it reducing the damage. My last mutation was Coup De Grass which I have on just because more crits = more damage, but I'd maybe recommend a more fitting damage mutation. I'd recommend either an axe for chopper or toenail scimitar for blademaster.
Beyond that, I'd just recommend having a good set of meaty smoothies on your action bar. I did pop a couple in my fight. The widow has a stacking poison that will just get worse as the fight drags out. So if you can't reliably block her attacks, I'd be tempted to say that going all-out and face-tanking the damage with smoothies (+ladybug healing bonus) would be more viable than playing it defensively.
Beyond that, couldnt tell ya. Bastards hurt.