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Also dont forget the guard dog mutation for the damage boost in javamatic, and use a "+defense event" science trinket as it's a +100% damage boost too, it's huge.
Repeatfarming boss (broodmother) gives 3k science and 1 ooze + 1 other thingy.
i don't recommend this method
The quote from Lord of the rings Gimli: It still only counts as one is the golden rule here.
I have a red ant mount + stuffed red ant in front of their hill on a rock and i just go wild over there with some spicy weaponry. I go south past the golfball and start killing tons of mites, hop on the log and kill so many more mites before going north of the big nasty puddle where there's more mites and large amounts of larva.
Every special you kill is 3k raw science doesn't matter how big or small.
7 kills = 21k science and you need 20k to duplicate a fusion crystal.
I tried farming brood and see how many fusion crystal i earned in X time and this farm small fry method. The smallfry method is better and eazier.
if you get the sour broodmother things might end badly and you end up wasting time
When it comes to weaponry.
Do not uprade both fresh scimitar and fresh scythe of blossoms
it costs 3.1 million science to get a weapon from +9 to +15 while duping a weapon cost 6k.. Upgrade 1 fresh weapon then dupe it for both.
personally i have kept my fresh scimitar +9 and am upgrading the breathslayer since its finale impact appears quite good to me (+11 and going)
I would recommend getting a weapon of each element to +9 and upgrade it.
like in the previous mention --> sour is super effective vs O.R.C. Loads o players go for the 2h sour-axe since its final hit increases your atk speed quite a lot for a little while making you truly zerk.
On an offnote.
In game settings you can set crafting to free. Haven't tried this yet since it's a permanent change and locks you out of some achievements. This could be a way to remove the grind entirely