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If I'm serious about developing a keeper hospital thru multiple stories, would I be best off getting the pharmacy expansion right now and putting it in early?
I'll second this. Opening the night clinic early on is definitely not a wage drain and you certainly don't need to wait until hospitalization.
If you are at an early stage of the game (before opening specialized departments), you don't even need the tech and the radiologist. Maybe not even the janitor. The pharmacist is expendable, but if you get a cheap one with a loyal trait it's usually worth it even if you don't have that many patients. Just one antihelmintic prescription will net you $300+. A single doctor will do the job. If you hire an expensive one with advanced diagnosis, you can fast forward through the night and only have to worry about the odd contusion that your doctor can't pick up by herself. Alternatively, you can create an intern with the Loyal trait (which will be super cheap in terms of wages) and just take over with Doctor Mode. Your biggest issue will be Athlete's Foot vs Nail Fungus, but there's no penalty for misdiagnosing as the treatment is the same.
In my opinion, the biggest advantage of the night clinic is that it takes some load off your day shift as you move through the first insurance objectives very quickly and start getting more patients.
If your patient intake is 30, it's 30 for the entire day. If you have a night clinic, you can spread that intake over the course of 24h. If you don't, all 30 patients will come during the day shift.
Absolutely. There are actually many things that can't be diagnosed without labs and radiology. If you're playing the game as realistically as possible, as you mentioned, you need them early.
I am just banking on the fact that it's possible to game the system early on to solve diagnostic issues (apart from Athlete's Foot vs Nail Fungus), because every "can't diagnose" situation will be like one ER condition vs a specialized department condition, and you can't have a patient with those unless you open the specialized department.
For example, if you only have the ER, and your doctor cannot decide between Arm Contusion and Simple Fracture of the Arm, it's always Arm Contusion, as the fracture belongs to the Orthopaedy department. If your doctor can't decide between Giardiasis and Lactose Intolerance, it's always Lactose Intolerance, because Giardiasis is an Internal Medicine disease, and so on...