All enemies?

[evil_dolphin]

on some levels there are enemies you can avoid fighting, should i? i should i aim to defeat them all?

[Iron Cookie 53]

If you have dice that always land on 4 or higher while playing as thief and while fighting a Cornelius, activate the one hit KO bomb before the Cornelius does the same to you!

[Iron Cookie 53]

Sometimes you may have to avoid fighting all enemies in order to get to the boss fast. But if you want to get maximum power by trying to defeat all enemies on the floors, Knock yourself out! Not literally.

[jdr196]

There are usually just enough enemies to get you one level up. However, if you take only the mandatory route, you will fall short of max level. Personally, killing all enemies is a net positive, barring certain game modes.

[twins10]

you should allways aim to defeat all unless you absolutely have to avoid one to not die.
if you miss even one enemy you dont have xp to reach level 6 so you are going to reach the final boss without healing just before him and probably have less then full life and you wont have the last level bonus.

skipping enemies also means less gold to buy stuff like healing and upgrades and having your level up heals in less useful places.

if you did skip an enemy however your new goal on floor 5 is to open a path to the boss with you as healthy as you can and skip all other enemies unless there is an anvil you can reach and something worth upgrading, this is beacuse you dont get the last level up heal.