Enemy Randomizer and 2x speed mods are incredible in this game.

[Bonzo The Brown]

So intense that I could only do 1 level a day, before getting lightheaded.
Sets your brain on fire like electroshock therapy.
Makes the game feel brand new again.

Over time, the randomizer has patched in all the dlc enemies to the rando pool - you fight mobs/bosses you don't have the intended skills for dealing with them yet in the campaign (dash, sentinel hammer, supershotty, etc) preventing the use of default strats.

The randomizer mod was easy to install and auto-enables the cheat console so you can kill off the occasional mob that spawns in a wall.
For some reason, the mod is located here:
https://discord.gg/s95Ay55TbQ

Tip: make your first gun mod precision bolt, not micromissiles.

[UNBREAKABLE]

Can vouch. It's been my goto replacement for the previous randomizer mod that hasn't been updated.

If you use the tool that lets you generate your own version of the mod there's lots of options in the config file to remove demons you don't want, how much fodder spawns, whether spawns use a seed, etc.