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Ok, and? It seems completely arbitrary who has it and who doesn't.
The reason why the facility has a lot of infected people is because 106 occasionally breaches containment to spread the Pestilence.
My canon: 049 sees the need to escape as the pestilence. Anyone who is discontent with their existence and needs to change something or leave behind something is automatically in desperate need of curing.
For example: experienced Foundation scientists in their ordinary work environment are not in need of the cure, as they don't feel the need to leave. Meanwhile, Class-D are prisoners, so they naturally want to get out, one way or another.
Anyone trapped in a facility undergoing a containment breach is automatically affected by the pestilence, as at that point, everyone wants to get out.
Three guards in a blacked out room. Pestilence.
A researcher roaming the quiet halls. Pestilence.
A Class-D with everything in place to escape. Pestilence.
A response team scrambled. Pestilence.
Or a Mobile Task Force entering the facility.
They're all infected with the pestilence.