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Personally i'd suggest normal playing on normal up until about New York (Third mission). Then once you're comfortable, restart on hard (If you really want the difficulty spike.)
Or you can start on realistic straight off the bat if you're an absolute masochist.
But most of all just start and play the game; get a feel for it; only then will any advice make sense
Also, I just realised I didn't reply to op... Hard is the hardest difficulty, realistic is technically easier than hard.
Hard will up the health as well as damage done by npc's which will give you as the player a handicap per se. But realistic will give both you and npc's the same chance at life, making the game "realistic"... Hope this clears the confusion up a bit.