+all stat items are OP

[Piranha]

Growth Juice, Prayer Beads
Utterly trivialises the game from second loop and onward

There's a reason Spinel Tonic only provided fixed stats boosts, and even then it is extremely strong (perhaps also a bit OP)
Seems the mechanic itself "of adding to base stats" is the cause, as it provides a too strong power multiplier

[Liro Raériyo]

other then the 20 defense spinel tonic doesnt provide a fixed amount, it provides a multiplicative amount, all of its stat modifiers unlike every other item in the game are applied last and multiply everything, that +70% attack speed bonus? well if you have 10 soldier syringes boosting your attack speed from 100% to 250%, its now increased by +70% to 425%, not just adding 70 to reach 320%.

Get a Rejuv rack increasing your natural health regen to 200%? the +300% from spinel tonic just boosted that to 800%.

Spinel Tonic wouldnt be that great if it didnt do all these things.

[Bug Guy]

Thats the point of the stat boost items though, they are differed strength (though growth nectar is still good to get early as long as you have at least 1 buff, but still much weaker than many other reds in terms of power spike). If you are behind and need a turn around item, getting a stat boost usually isnt going to be enough. They are a win more item, if you are already doing well, they allow you to keep ahead of the curve. Of course they will be better on the second loop than say a single AtG, but I would much rather have a single AtG than a prayer beads on my first loop, especially if Im just going to beat Mithrix or another boss.

I think its important to remember that this game is really not balanced after youve looped twice. There are too many ways to break the game. If you are finding the game too easy when you are looping that far, there are artifacts that can add additional challenge so you dont get bored.

Sidenote, all Lunar Items are broken because they exist outside of item economy, even the bad ones