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Also, there is that thing with farming hidden stages ;] You know, time stops there so you can stay as long as you feel like it....
just for point of reference I was doing a sacrifice command run with engi last night by the time i got to sky meadows on the first loop i had like 15 items 1 of them being the legendary chest and 5 of them being teleporter drops (1 shrine of the mountain on stage 3)
by the time i got to stage 11 (aka 1 stage 3rd loop) i literally could not pick up items as fast as they were dropping ( i play with a controller and that means you have to jump to select each item with command) by the time i hit 140 minutes into the run i had over 100 syringe teddy crowbar and like 20 of everything else thats relevant except for soda's. plus over 150 green items and idk 15 red items.
TL;DR sacrifice makes loop one harder then turns into a lootsplosion gamemode making it basically impossible to lose.
There are modifiers that reduce chances, like spawning in the teleporter fight, but the minimum drop chance is also 5%. If you want earlygame items, triggering the teleporter immediately and farming enemies from there is a good way to go.
Bum rush tele and just move on to the next stage because sitting around isn't gonna do anything for you.
If you want to get really cheesy then use Artifact of Kin so boss is a horde of monsters so your chance for drops increases more.
In general I hate loitering around in the first two stages. If I'm not on the third stage by 9 minutes I start to get really antsy.
Also, one of the big advantages of sacrifice is that you don't have to waste time farming and looking for chests, you can rush teleporter every single time. It's a good trade off for having less items early on.
If you run it with swarm you get a lot more items. It's not a clean double, but early game it's close. Woolie did a video on it. Basically Swarm cuts the Difficulty rating of each mob in half, but the 5% base is stil there. So early game when you're facing weak enemies with nothing more than the base anyway you get about double items for the first 2 stages. And late game Sac is amazing anyway, and Swarm makes proc chains even more OP. Although Swarm/Monsoon is pretty belligerent in the first 2 stages...
The lowest drop chance for any normal enemy also can't be below 5%, period. Any naturally spawned enemy has a minimum chance of 5%, no matter how much they cost to spawn.
Sacrifice reduces the chance by a bit, but because of the 5% minimum chance, it doesn't affect normal enemy drop rates, only elites. The extra rolls from more enemies is worth more than the loss in each roll's individual chance, iirc.
In general, this means that the longer the run goes, the more items you get, but early game it's entirely based off of RNG, because the percentage chance that a given lemurian or wisp drops an item is pretty low.
Source : https://riskofrain2.gamepedia.com/Artifacts#Drop_Chance & having looked at the drop chance code myself