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I don't really like Ion Surge because you lose half your damage and damage uptime, so not only will you be missing out on Artificer's inherent damage, you'll be doing nothing more than half the time.
Generally I don't really have an issue with playing CQC Artificer with low mobility, but from what I've heard it isn't a common strategy, thus why people use Ion Surge.
First and foremost is a dedicated Shaped Glass build - once you have enough Shaped Glass to bring your Max HP below your passive healing, you effectively have permanent One-Shot Protection. This will help save you from the vast majority of *normal* attacks, while also providing enough damage output to quickly dispatch more dangerous threats. I believe 5 is generally a good number, or somewhere in that ballpark. You can always take more, because at that stage you're going to die to basically everything that does DoT anyways.
Second, play with friends - I'd recommend 2 players as it's just enough extra goodies to help sculpt both builds effectively, adds a second layer of death protection, and doesn't push enemy generation too far out of control too fast. It's, in my opinion, more manageable than solo and less crazy than a full team. It's also useful to coordinate item locations, chest contents and enemy management with good communication.
Third, you're going to want a dedicated Gesture of the Drowned setup. One Gesture plus any combination of 3 additional Gestures/Fuel Cells will give you permanent uptime on Spinel Tonic, this will give you a very, very hefty boost in stats, especially regeneration. Besides Tonic, Royal Capacitor is your other S-Teir Gesture build - you kill most everything just by looking at it.
Fourth - aim for 100% crit chance. You're bound to pick up some number of Scythes and/or Predatory Instincts and that equates to free damage, free boosts in attack speed (and thus animation time reduction) and free healing, all of which help keep you alive.
Fifth - many, many Tougher Times, you can never have too many, really. At least one Stealthkit is also useful in keeping aggro off you.
Sixth - drones are useless for DPS, but they are extremely useful for drawing aggro. Every enemy attacking them is one that isn't attacking you. Queen's Gland is basically a respawning damage sponge.
Seventh - 57 Leaf Clover. 'Nuff said.
Eighth - If you've got sufficient Lunar Coins (you should) pay close attention to the Lunar Seers in each shop (you should be going to most of them). Sometimes Golden Coast will be offered and Aurelionite is good to have. We call him Big Friend. Always have a Big Friend whenever possible.
Finally, go fast, be efficient and don't be greedy. If you're not instakilling most everything, figure out why and start working on fixing that. Don't be afraid to take a first Shaped Glass if you have none, just be sure you have the fast healing necessary to recover and if you don't you might want to consider more Glass until you do.
Edit: And oh yeah, luck - luck is very useful. You're going to want quite a bit of it.
With 1 Gesture of the Drowned and 3 Fuel Cells/Gestures on top of that, you have permanent uptime on Tonic. That means it never goes into cooldown, you never get an affliction. Additionally, the affliction goes away while Tonic is active and only applies while it's off, so with permanent uptime, that never matters anyways. You will ALWAYS have a buff to your stats all of the time.
If you use this strategy, you may wish to learn to properly time your teleport out so as to have minimal downtime coming out of the teleporter as it will take anywhere from 3-5 seconds to reactivate when you reach the next stage and that IS enough time for something to kill you.
The only tough part about that is luck. You don't get to choose your regular items, so you can only hope.
There's also a commando challenge to finish 20 without blues. So it's definitely possible, just more luck based hoping you get a good assortment of items.
this requires very good luck though, i guess.
get like 20 of them and you should be good
this game is based around luck. if you dont want luck to influence your runs then way untill march brings the command artifact that lets you pick your items from the box
This is most effective with healing items.