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In my experience to have the best chance of beating the encounter you want a decent trait rank. This is because you have to both draw as much aggro as possible and kill as fast as possible. It's also vital you aggro / kill certain key enemies like the exploders, exploding ball throwers and the machine gun brute. If you let them pile onto a Liz your likely to lose.
My advice is to do it on normal and play solo for fast kill times. If you have the right kit then run a pet build using turrets and tentacles. Sprint straight down the middle from the fog. Try and clear the area and acquire the Liz's. Then drop the turrets on the left hand side upward ramp. This is a great perch for them to slow down / kill trash mobs (including the exploders). Drop a tentacle in the left hand side underpass. This will kill any trash wandering through.
Once the above is done if both Liz's are on the left its just a case of going all out killing and refreshing the pets. If one Liz goes far right it gets much harder and you'll need to leave the pets to hold the fort and go try to keep right hand Liz alive (this one always seems suicidal!) with just shooting and your one remaining tentacle.
Even doing all the above you can still lose but you will get it eventually. The key is to just go ham, use pets to be where you can't be and take out the biggest threats yourself. The fact you say there getting killed by exploders means your at least not doing the correct prioritisation. There one of the biggest damage dealers and also the easiest to kill. So you should be expecting them to arrive and killing them all in a few seconds assuming the turrets don't do it for you.
This.
You must make the monsters aggro on you. If they go after the Liz's they can die. You also have to get lucky that one of the Liz's doesn't decide to get stupid and try to fight it out with a monster up close and personal. If the stars align it is easily possible.
When the nut sacks spawn pop a frenzy dust and focus on them. Same thing with the elites. Using Rattle weed were would be very effective here.
If you dont have it, play earth adventures until you get Shroud boss. It should be the 1st one you face so shouldn't take long to find.
I know it can be done, but I couldn't manage it. Fortunately the locked door was bugged so you can glitch through it. Dunno if that ever got patched.
The Trick with staying ant the entrabce works wonders.
Every other time I just killed every enemy I could see ASAP, prioritising Bursters and Elites.
If you're having that much trouble, just keep an eye on the NPC health bars that are clearly displayed, and use Liquid Escape or die by enemy if one croaks. You can retry that way.
Swarm, Breath of the Desert, Rattle Weed, Stormcaller, Hunter's Mark, and Howler's Immunity are all decent for this fight.
Chicago Typewriter is godly with Radiant set.