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If you are going to use Mega Scans, I would suggest going with a 100% Mega Scan setup, because this will indeed be a problem. Four Mega Scans are usually sufficient, plus maybe a diagnosis Ward. (This assumes your GPs are also running efficiently.)
I remain of the opinion a pure Nurse room diagnosis setup will be better, though. (Feel free to disagree.)
Depends on the hospital and the illnesses it possess
To the OPs question, MSI scan (MEGA scan in game) is better for diagnosing patients of certain types (linked a good guide below). If you have large queues, just double up. Its good for smogley to have MSI rooms for diagnosis as they have a lot of surgery patients if I remember correctly.
You may want to check out some of my posts on in depth analysis on this:
https://steamcommunity.com/app/535930/discussions/0/1743355067102603544/#c1743355067113852613
https://steamcommunity.com/app/535930/discussions/0/1743355067107032474/#c1743355067107308638
https://steamcommunity.com/app/535930/discussions/0/1743356517524271908/#c1743356517526537940
Also there are wonderful playthroughs on youtube and guides on steam which help out a bunch. I watched YT Blara and Geekism the most at the beginning of the release (and prior) of the game. Plus reading through guides such as Frieya's Illnesses guide proved very helpful to me and is the basis of my help in the above links. Plus over 200 hours play :)
Frieya's Guide
https://steamcommunity.com/sharedfiles/filedetails/?id=1519429114
Blara -
https://www.youtube.com/playlist?list=PLmSsM7C3keqxyn1T56B0ioIg23V85RMyG
Geekism
https://www.youtube.com/playlist?list=PLak7UKfYySPGwn2tBrbiID0V7GYQvug7x
Quill18's
https://www.youtube.com/playlist?list=PLs3acGYgI1-vJKq8MliYKsNs11V9q6f7Q
If you have further questions, just ask.
OG