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I would say the Food Processor and Mini Fridge are often my most prized possessions unless I'm playing one of the few classes that can't eat food to heal.
The Ammo Processor is a must have when playing a ranged weapon class, and the Melee Durability Spray is awesome to keep those Swords and Axes (and the occasional Sledgehammer) from disappearing on a melee weapon class.
The Resurrection Shampoo and Quick Escape Teleporter are very nice for saving you from ending a run prematurely.
The Timed Explosives are also quite enjoyable for dealing with several enemies at once.
The Giantizer is always fun for some lulz, though for some reason I actually don't always use them even when I find them, and even less so since the nerfed duration.
I'm also fond of the Hologram Bigfoot, for getting NPCs to fight each other or to destroy an object w/o turning anyone hostile against me.
ressurection shampoo would definitely be #3 for me, i favor more offensive solutions than defensive given a choice though i guess.
My #1 is definitely the tranquilizer gun. Ownership of one of those is very nearly worth a class, all by itself, as there are a ton of missions that become trivial when you have it. Even the ten-second delay is a feature, not a bug, because it gives you a chance to be elsewhere when the bodies are discovered. And you can even use it in active combat, if you're a fast character who can outrun your enemies while you're waiting, or you can use it twice for instant effect.
Also note that you can still use the Kill Ammunizer/Healthenizer/Monetizer with the tranq gun. After they're down, just kick them a couple of times and they'll die. You won't get any XP from them, and it'll rule out the "no kills" XP bonus, but it will trigger the kill gadgets.
It's especially good on a Hacker, since the missions that the tranq gun make very easy are mostly complementary to the missions that the Laptop makes very easy.
After that, my favorites are probably the Skeleton Key, the Rocket Launcher, and the Time Bomb. As the tooltips say, sometimes your best option is just blowing it up.
I just wished there were more effects.
Word up to this, big time. Water Gun + Cyanide Pill is ♥♥♥♥♥♥♥ OP. I mean, for real, EIGHT shots for one pill? EIGHT silent, instant kills? Tranq gun is dope, no doubt, but I'm putting my support behind the water gun.
On the other side, Tranq has a much lower maintenance cost...cheaper ammo and also refilled by the "Ammo Gadgetry". But yeah, both of them are OP af.
As for best item, the only thing that classifies as such for all classes and situations is Ressurection Shampoo (which I strongly feel must be removed from the game). Other things that come close are Skeleton Key (any door), Sledgehammer (any window), QE Tele, Kill Healthenizer.
And my favourite "item" is the toilet that you can carry and fling as Wrestler...just too good :D