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If you want a game, buy Pathologic 2, if you want a book\philosophical thesis (and a good one, mind you, though I should warn you that it might rearrange stuff in your head a bit) - buy the first one
-Graphics are decent, however some optimisation issues arise.
-Actual gameplay is a lot, lot, lot better and a lot less frustrating and unfair than Patho 1. It's still hard, but it's hard without being cheesy or straight up unfair.
-Individuals, including Ice Pick officials, say that Patho 1 was a bit of a botched English translation. They believe they have translated things a lot better in Patho 2 than 1. Keep in mind that this is a highly allegorical piece of game, so the dialogue rarely bluntly states what is happening. For this reason, use of translation to capture all stylistic figures adequately is important.
-There's a free DLC (Marble's nest) that ties in with the story a bit.
Why get Patho 1:
-The cult classic.
-Patho 2 currently only has the Haruspex's storyline. Patho 1 offers the storyline of all three healers. However, Ice Pick Lodge has said that they will make the other 2 healer stories for Patho 2. Only a matter of time. However, they might come out as DLC. For now undefined.
-I have read on the forums that some people believe that Patho 2 and Patho 1 in their contents and philosophies vary differently, stating that Patho 1 is highly abstract, discussing captivating matters of life. I have only seen this argument once or twice, so I'm not sure how many people find this to be true. I cannot comment much, as I've not played Patho 1.
The philosophy behind the games is quite different. The main storyline hasn't changed that much, but the world and setting had improved, and there is a new tonality to the second game.
The game has evolved in terms of its philosophy, according to the game's mastermind Nikolai Dybowsky.
I would say, that the philosophy in the first game is younger (obviously), has an edge to it and a bite. It's daring and without many compromises. The second game is more wholesome, but it is also not as sharp as the first one. While the gameplay may have become harder, the ideas are a bit more forgiving and easier to understand. There are still a lot of quite innovative ideas in the game, but they were diluted by more mundane motives like family, friends, love and kin, so the player is not required to constantly crash his view of the world against the author's view anymore.
The best way to describe it is that if the first game required master's degree in literature and philosophy to be completely comprehended, the second game only needs you to be a Bachelor ;P
That's assuming you have a degree. [screenshot of Bachelor asking if you have a degree meme].png
"asking if you have a degree" in latin ;P