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Using human abilites+alien ones in a combo is the best eg.bullet time+alien shield+psi disable+dmg spell+few shotgun shells will kill the nightmare very fast on nightmare difficulty and you can tank a few hits via spell.And you can even have resist dmg type passives and regen back some dmg.
Morphing into object or into operators via high lvl mimicry can allow you to reach more areas.
That said there is an achivement for completing the game twice once with only human then with only alien skill.
Human skills are more practical.And some items can be used to disable psi,machines etc.
You'll save a lot of resources not having to make as many neuromods as a hybrid build so those can go towards ammo and such instead.