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1) if your question is what is my goal, your goal is to dig to the surface (up)
2) if your question is how do I survive, i will say that I began many times and made many mistakes and restarted (so you can do that too). In the end, for certain in the casual mode, I think it's not possible to "end" your game - you won't run out of anything, you can always print more dupes, so, experiment, prepare to have colony crashes, but hey, they are only duplicants, right, they aren't real people, right?
most of the information is on the popups, and/or can be figured out with a little experimentation, but a lot of specific information is not included. the wiki is your friend https://oxygennotincluded.fandom.com/wiki/Pitcher_Pump
Big picture: don't try to do too much too fast. More dupes can do more stuff, but early on the extra food/oxygen they need is probably a bigger cost than the extra work they provide, stay with just a few. Once things start to seem smooth, you'll notice things are getting too hot. Plan ahead.
I am quite far along (I think) and I don't know what happens next.
DLC SchmeeLC.
For example you get that oxylite at the beginning but it will soon run out. So you do kinda need to rush to get a new source of o2. You can use that diffuser but it's effective but inefficient. So build it, but at the same time be researching for tech to build a better o2 generator.
In my experience I am building for the next thing and meanwhile the old thing breaks down and I have to tend to it before construction resumes on new thing, in a constant juggle between new stuff and old stuff that needs to be reworked or upgrading old to new. Then when I get the new thing working, it has a problem so I have to turn the old thing on while fixing the new thing. Just keep trying to move forward, with the chaos and setbacks (disease fatalities etc).
https://oni-assistant.com/guides/starter
Remember, like real life, an area can only hold so much of something. It isn't terribly important where the oxygen comes out of the diffusers, the problem you're having is that area is already filled with a gas, probably carbon dioxide. CO2 is heavier than O2, so it rests at the bottom, and it sounds like that's where your dups are running around. A very, very, very common issue new players run into. What you need to do is dig down a layer or two, so that the CO2 can fill up at the bottom, leaving all the space above it for O2, where your dups are. Since O2 is lighter than CO2, the O2 will force the CO2 down to the bottom. Eventually you'll have tools for dealing with the CO2 itself (scrubbers, take a look at those) but you won't have to worry about that too quickly.