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I don't open up these large strip-mine areas to the general non-suited population until 8-10 floors are clear of Slimelung.
Also, if you don't destroy them all at once, the ones remaining will more than likely consume most of the released gases.
If it's an extremely small amount of polluted oxygen then it will just die off.
The germs also die in cold temp. So pumping your oxygen into an ice biome might also work but usually the standard cleaning with air purifiers is really enough. Don't worry too much about slimelung. Just make sure your dupes don't get a motherload of it. They can handle smaller amounts just fine.