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vaccs is gamebreaking when used in niche low-playercount scenarios where you can completely shut out specific players
quickfix is similar but more generalized and gets its strength from deeper health pools and an unkillable medic rather than blocking damage
kritz is just generally situational but doesn't have the buff drawbacks of the other two
none of the above 3 should be used when you're trying to push a defensive hold with sentries and heavies/demos/pyros involved
do everyone a favor and always use the medigun unless the rare situation comes up where a different one would be better
Any of them is pretty good.
Kritzkrieg is designed to counter stock with faster ubercharge rate and is great for defending
Vaccinator is for fast, small pushes
Quickfix is a counter to pyros and the best choice for casual and pocket medic
Stock is in the most situations the best
You can't say Mediun XY is the best, because they're designed for spezific things