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Failing that, there's two wands and a helmet that each grant a limited number of uses of the skill Purge. (I think on classic the wands gave you three shots each and the helmet was unlimited, but in DE I'm pretty sure all of them give you four, a decent upgrade for the wands and a big downgrade for the helm.) You must explicitly use this skill (on default gameplay settings, it should automatically appear on your skill bar when you've got a character equipped with one of these items), not just try to attack them with the wand. One use of this will destroy a shrieker outright. It has other uses but none that are nearly as nice as that one. If you find even one of the three relevant items and use it judiciously, you'll have enough uses of Purge to get through to the fight with Alexander and the Voidwoken Drillworm safely.
A little later in the game you get the skill Source Vampirism, which is essentially the same as Purge. From that point you can blow up a shreiker any time you've got a Source point to spare, so they become much less threatening.
Once you equip the wand with the purge ability, it will give you an ability called purge. It will be a green icon with some vampire teeth. It will be on your hotbar. Some items in-game can give you some skills, this is one of those items. You use the ability the wand gives you on the shrieker. This ability is powerful and is limited. Not all items with abilities are limited
Why would you not just look it up on google instead of replying to a thread from six years ago