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well in game and on the wiki it specifically states "will spread to other nearby characters" so yeah i think it has friendly fire unfortunately. AND i ended up testing it myself and currently, at character level 11, it reduces constitution by 3 and damage by -35% (which is significant). it is also resisted by physical armor. so it is still useful if you can shred enemy armor while keeping your own up. lowering their damage by 35% but keeping yours the same. like my current party is 4 summoners, and as most may know incarnate champions have a ♥♥♥♥ ton of armor with fortify and infusions. so i don't care if my damage is reduced by 35% so infecting myself and all the enemies doesn't matter as long as my incarnates are unaffected.