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Your reputation can drop from your actions, but almost never enough to make people instantly hostile to you. Even when you've decided everything against a faction, they'll remain neutral 90% of the time (until you shoot at them of course). There's a few achievements that will give certain factions a low chance to become hostile, but it's very rare.
Killing stalkers out in the zone will not affect your reputation, no matter who you kill. It will turn them and their squad hostile to you, but word does not travel around the zone apparently. The only exception is attacking stalkers near safe zones like the boat, Skadovsk. If you kill the guards for the safe zone or shoot stalkers too close, the safe zone will lock down for quite a while, and when it reopens, your reputation will be reset to neutral. Since the quests are unique, this means you can wipe your progress with a stray bullet. Be careful.
I'd recommend making sure you know who you're helping and who you're hurting before taking a quest, also keep in mind that none of them are time sensitive so you can take your time deciding things.
The only mission that is time-capped is a money earner and gives no reputation for failing or succeeding. That's the artifact order repeatable "quests"
They can also frequently bug out from the death of necessary NPC's if you wait too long with doing them, so it's always recommended to get to them sooner rather than later to make sure nothing goes wrong.
As for OP's question... Yes your reputation with factions will grow as you help them. From time to time you may get achievements if you side with a faction and help you enough. This will then give you different rewards like discounts with appropriate traders or having them help you in combat more frequently. On the flipside, factions might turn hostile to you from time to time if you do too many missions against them. You have to judge the pros and cons of helping certain factions to see which might benefit you the most.