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Not all the games or mods in the series are like this. For example in Cop Misery just having that artifact in your inventory not even equiped will start poisoning you with radiation. So there are these 5kg steel lock boxes that you need to transport them in. Then if you want to wear one you have to put it in an actual artifact container which will filter out the rads but also weighs another 3kg. So equipping a single artifact that might barely help you is a good 5+ KG of weight in Misery.
In shadow of Chernobyl you can wear like 12 artifacts and they dont have to be in armor and just go nuts. There is no penalty for having them in your inventory like in misery.
Jellyfish
Wrench
Bubble.
These three artifacts have no bonuses other than unlike other artifacts they DRAIN radiation.
Once you have these its all a matter of balance.
Make sure you are loosing more radiation then you are gaining and not only can you wear artifacts with no penalty, but any left over rad drain will stay essentially letting you ignore minor radiation.
Radiation in this game acts as a slow posion that is constantly getting stronger, without a counterbalance NO health regen short of a medkit IV will keep you from dying.
Also bear in mind that there is health regeneration(as it says) and wound healing(bleed prevention). these can be a bit confusing.
if the amount removed is more (or equal) than the amount the other artifacts give, youre good
Artifacts are very useful and can aid you greatly.
Artifacts that heal you, artifacts that boost stamina regen, artifacts that boost resistances to your weakest anomalous protection or push your strongest further and--my personal favorite--boost carry capacity.
You can ignore them if you want, but that would be disregarding an aspect of the game.