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The 'best' is probably Mayhem 6 and 11, because you unlock pretty much all available weapons in the game.
But, in the end of the day, its really all up to you. Playing on Mayhem 10/11, you need very specific build. Which pretty much limits you to those weapons/gear/skills. There is really just a few builds that actually work when you go up that high, which means that you cant use like 99% of the items/skills in the game.
Its fun for some, but for me personally, I like to use the skills and gear that is FUN for me. That just doesnt work on the higher difficulties.
In the end of the day, its your game and your free time that you use to play it. There is a bunch of people who dont even like to play with the Mayhem, and than there are a bunch of people who cant play the game unless its on Mayhem 10/11. Go through the levels and find your sweet spot, where its challenging enough to have fun, but not 'pull your hair out' frustrating.
I feel that pain. I'm in jackpot DLC mayhem 11 with Zane. My digi cone melts everything while I just tickle it.
I only have first season pass and I read that you'll have more end game gears if you own both seasons.
But I agree with the person above who mentioned Arms Race. If you can farm a Plasma Coil at M11, that should make a huge difference.
Like others said, it seems Mayhem level 4 or 6 is an optimal level for a person like me because I'm not too smart with character builds yet for level 11 so I guess I will stay at that level until I learn all the stuff about character builds and the best weapons and try to grind my guardian rank so I can optimize my character for level 11
Then Mayhem 6 to get a Plaguebearer drop from The Warden.
That weapon can assist softening up mobs.
Then you have the seasonal events which you can turn on to get some good weapons.
Joey's Villa for eridium.
...but I prefer Mayhem 11 because it doesn't have modifiers and i have all the DLC so can access the best gear in the game and solo everything at the hardest difficulty settings.