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there are weapons and stuff in Base game you can only get with mayhem 4
https://docs.google.com/spreadsheets/d/1fkCwu0zeX1BBGcNEzWGZDr2kQ0IOPSoZQK2FD-zpw1M/htmlview?usp=sharing#
Once you can activate mayhem mode, all areas scale to your level so you can go back and refarm for on level gear. You just can’t get quest rewards, however once you’re level capped, switch to TVHM, get to Sanctuary III & you can go through it at max level even with Mayhem mode for better/more anointed gear
If you are dying to buy more SDUs for inventory/ammo, the casino does seem to have a lot of money items, but at 50ish I'm getting anywhere from 2-8k a pop.