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You can take the mutate perk later when you've started finding two handed weapons. Not very efficient in fallout 2, but good in fallout 1.
Still, if you're looking to min max and focus on a certain type of weapon skill rather than weapon class, its not really worthwile. The perk is still a very situational, compared to other more usefull ones like like Fast Shot, Kamikaze, Good Natured, Finesse or even Jinxed.
So while your argument for playing ranged weapons is true its also fun sometimes to be a drunken brawler just beating people to a pulp.
In Fallout 2 however its a great perk since there is a expanded range of weapons. Weapons such as the Gauss pistol which deals less damage than the rifle but matches in range, and costs less to fire. The damage can be negated by the fact you get a free 20% accuracy bonus on shooting people in the eyes and blinding them which instantly removes most characters from even fighting.
And even then, its not the best pistol in the game since the Needler Pistol (available as early as Redding, the location is given in the Den by Tubby) exists and has Weapon Penetrate + the AP Needles does double damage, which in terms of damage surpasses both Gauss Weapons.
Also, boxing gloves and the plated version use both hands according to the Fallout wikia pages for them, so I would think that using One Hander would hamper your effectiveness in boxing.
Once you grab the Sniper perk the Needler looses its advantage because now the Gauss will bypass DT and DR by the same amount(assuming you grabbed better criticals to ensure every shot bypasses DT/DR).
Gauss 2mm ammo increases its damage by 50% Giving the Gauss final damage 33-48 while Needler using AP ammo will be 24-48 so the Gauss will do higher average damage over course of combat.
This coupled with the Accuracy bonus of the Weapon perk and the -30% AC (Needler gets 10%) modifier from the 2mm, and the longer range of the gun means the Gauss is Easily better.
So the Needler is a good choice if you want to play a run where you don't choose the Sniper perk.
Besides, I use the Needler straight from Redding to the end game with bo problem, you can bring up numbers all you want but clearing difficult areas at low levels and with ease for massive XP boost with ammo better available and cheaper than the 2mm EC.