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pretty much if you go to NG+ then you can skip mark 5 and jump into mark six
it only really maters while you are staying in your current NG cycle. so i would pick your fav. weapon then whatever else you feel like spending it on.
pretty much as soon as you start your new game + you will run into mobs that drop mark 6 teir drops and will be able to upgrade any of your gear to that point
Some favorite sets are.
1: NG gorgona, for its stamina regeneration
2: Lynx, for better attack speed
3: Chrysalis, adds heals to finishers
4: Aagel, gives one additional consumable heal
My personal favorite sets are
5: Bloody proteus, adds 20% to all healing effects (just for its looks)
6: Mantis, lowers energy cost for most implants
7: Iron Mause, 0 core consumption
notes to take
Sunglasses and Mascot heads do not disrupt set bonuses.
MK X and MK XV nano cores can drop from Nanite mass/blobs in NG+ and on. They can drop in NG as well but are extreemly rare.