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Sirris' and any other quests are just tied to the current NG/NG+ cycle. So when you go to NG+ 1 or 2 for the various rings needed to 100% that you can't get in a single game cycle, you can do in a 2nd cycle.
The only one I can think of that might have farther reaching consequences in a NG+ cycle is stuff tied to Yoel, but that still doesn't lock you out of any of the paths at the start of a new ng+ cycle.