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You can miss the upgrades for the Fragile charms
You can get locked out by (minor, then moderate spoilers) Beating a certain optional, difficult boss before upgrading, that being: ... Troupe Leader Grimm
Apart from that, some upgrades are VERY helpful to get before fighting the endgame bosses, but still not required.
Specifically some abilities have the effect of (minor game mechanic spoilers-)Granting I-frames.
These abilities being Descending Dark and Shade Cloak.
To clarify for OP, if you *do* defeat NKG, you're safe from being locked out of those upgrades, because (moderate spoiler - this is to remind people who have seen it already) Divine will stay behind for you to finish before following her master. It's if you take the other route where you don't defeat NKG that a save file permanently misses out on those optional upgrades.