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Also, he doesn't necessarily only play one card per turn. His base power allows him to play a second card, and he has at least two ongoings which allow him to play more cards during other turns.
I recomend playing him with Fixer, Argent Adept, or legacy to get a feel for him. He's weird and requires creativity but he is a lot of fun. Also helps to have disposible ongoings if that particular villain likes breaking your stuff.
His combos are achieved with either Super Ultra Kawaii or Selling Out (bonus points if you use both). Selling Out lets you play 3 cards at the end of the environment turn that share keywords with a card you discard, typically you use this to play ongoings. It is recommended to put Guise last so he gets full effect for these cards. Kawaii lets you play a card at the end of every hero turn (including Guise's own turn) as long as you have H cards in your hand.
Here is an example using both Kawaii and Selling Out with Guise in the last position. He has over half of his deck in his hand.
Guise's turn starts, he plays Best Card Ever! cause why not? Guise plays Kawaii. Guise uses Tough Choices deals one damage, plays Selling Out. Kawaii lets Guise play a card - Blatant Reference. Guise does not discard for Reference.
Enviro does worthless thing, Guise is the star here. Selling Out lets Guise discard XTreme, plays Guise the Barbarian, Total Beefcake, and Ughh Yeah...I'm that Guy and high fives Legacy (Inspiring Presence heals everyone!).
Villain does stuff like try to hit Guise, Guise redirects it to villain with lowest hp - who would want to hurt such a beauty?
First hero takes turn, whatever, Super Ultra Kawaii lets Guise play a card, Guise plays Where Did That Come From? hits a villain for 3 (one shot) +2 (Barbarian) +1 (Presence) +1 (Presence) Blatant Reference lets Guise discard a card, he discards Gimmicky Character deals a villain 1 (Reference) + 2 + 1 + 1 damage. Repeat for all other heroes until start of Guise's next turn.
Congrats, you are awesome. Set up for the next time. If you want to make Guise the star of the show, bring Team Leader Tachyon, regular or PW Argent Adept, Greatest or Finest Legacy, and anyone else just to give Guise an extra turn with his ongoings.
Anyways to the OP here is a guide I wrote out http://sentinelswiki.com/index.php?title=Guise_Strategy
Blatant Reference is not too impressive...until you stack it with Guise the Barbarian.
So heroes like Greatest Legacy or Argent Adept who can regularly deal him extra power uses are very welcome.
I usually put Guise first rather than last - that way he can play out the full weight of Blatant Reference or Super Ultra Kawaii before the villain turn hits. Last might be better if you're planning on leaning on Selling Out to play ongoings...which is a new one to me, I've never had much use for that card.