When to save guide?

[Bastila Shan]

When should i spend my limited ink to save the game? Every 15 minutes of progress? Can i leave a room that has a boss in it to go and save then come back? What are some tips from you veterans?

[LilG]

Save before or after fighting a boss. You can't leave a boss room then re enter I believe,unless that's been changed in the remake.

I used to save after I reached the court yard or roughly reached halfway,just before the final part of the game. If you're just starting out save around every hour or so. Just remember you don't need to carry ink ribbons with you,dump them in storage, they're usually near to typewriters if you need more.
Once you get used to the game you won't need to save at all.

It's usually a good idea to have multiple saves just in case you mess up & end up low on supplies.

[Nick Vascuas]

I'm no veteran but I wouldn't save if you are not sure where to go to progress. I would keep your saves until you know what you need to do or you have finished exploring what you think is all there is for your key/item. Such as one of the keys that are able to be discarded and you searched each room fully.

[Wyrtt]

Game is around 10 hours long on the first run. On normal you have around 25-30 inks if I remember correctly.
Just save every 30 minutes and you will be fine, But save only if you made some progress. If you wandered aimlessly for 2 hours and got bitten 10 times while wasting all healing items and ammo just to find key item 5 minutes away from a save point than maybe just redo that section in 5 minutes and then save,

[ut]

Save when you need to leave your computer, of course.

Do not overwrite unless you have to.

PS
Just my suggestion, you may want to save after getting certain items.
The first time you find a save room.
The 4 mansion keys.
The metal object in Spencer's room, before you save Rebecca.
Before you save Richard.

You only need multiple saves in the mansion, the residence, the tunnel and the lab are linear, you can just replay if you die.