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Yes it is possible on a single playthrough
Edit, unless your going for all the skins and milestones as well, than it requires 3 three playthroughs at minimum.
Every level is designed so that you can get everything in that level with what you have the first time you do it. None of the secrets require a specific weapon and all of the challenges are for something you either get in that level or got in a previous level.
You don't need to complete the level. Just get to a checkpoint and exit to the main menu. Your progress will save.