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1. If the Pawn does not have bionic/archetype legs already, install both peg-legs
2. Remove installed legs (human legs are part of the body, but bionic, peg-leg or archetype are items that can be manipulated/removed)
3. Leave them immobile in Hospital, until the withdrawal is complete
I found this method during my initial research of the game, and started using it recently. This way you can rehabilitate any Colonist or Prisoner, especially the ones you want to recruit.
Also, this can be used if the person have constant pain, broken heart, dead relative etc. Get them handicapped until the debuff is gone, being that addiction, waiting for mech serum, or getting REALLY tired of "Minor break" ping.
No tantrums or anything.
There are several methods to dealing with the withdrawal mood debuff. Many people tend to lock their pawns in prison, because an imprisoned pawn is limited on the types of mental breaks they can go on and are thus more predictable. For instance, they cannot go on the insulting spree or corpse obsession mental breaks while in prison. However, they will still get a moderate mood debuff when you release them for prison for a few days.
You could also prevent the pawn from walking for the duration of their withdrawal. Pawns who cannot walk are incapable of going on mental breaks. The late game way of doing this is to install peg legs on your pawn and then remove them, thus amputating their legs, and then installing bionics once their withdrawal period is over. However, you could potentially also continuously put them under anesthesia, but this would be quite expensive in terms of medicine and intensive in terms of micromanagement.
*writes this down as SOP for my future cult.. i mean playthrough*
This method is really useful in situations where there are a lot of people on the map, and prisoners are grouped, since storytellers have max number of present pawns before they start making social fights, breakdowns or berserk states within population. Cut prisoners legs, and what are they going to do ? Stand up and protest ? xD
Just to add, not every drug has same withdrawal, and I think psychite tea can be done standing cold turkey, but the rest no. Also, as Terripan wrote above, withdrawal is never short, unless you caught addiction right away, and it can take several months, even a year to fully recover.
Big thing I missed are Painstoppers, which can help greatly during hospitalization time, especially if the legless junkie has wounds or permanent injuries that cause even more pain.
But if the prison/hospital is impressive, they are comfortable, fed Fine meals and have Warden to socialize with them, there will be no issues.
If the drugs are necessary in the colony such as you making them to sell, then I will imprison the pawn with the addiction until they are over it.
If the drugs are not needed for money or morale, then I will just lock the drugs into a pod launcher. If we need them for something, I will draft the addicted pawn, and then eject the pod contents and have the other pawns do what they need to with them, and then lock them back up again.
As far as dealing with the mood penalty, You can use the word of joy psycast on them, or just allow them to have mental breaks a few times, or else imprison them.
A pawn that is genetically dependent on a drug can not be weaned off of it.
From my standpoint, I had never have a Colonist getting addicted, even now when I'm running Go-juice cartel, with Yayo as mid-product. It's always captured enemies that come with the addiction, so I really never had imprisoned my own.
As for leg cutting, bionic/arch legs are the goal for everyone, so I will just leave them legless until the addiction is gone, and I have space, gear and brand new legs to install.
Actually, I do not get how other players' Colonists get addicted during regular game-play, unless they are using combat drugs ? I've had Colonists with Chemical Fascination, but beer, tea, chocolate and even ambrosia kept them ok.
Last thing, addictions can be also cured via Mech Serum
I did have one person get addicted to beer because I set up the drug schedule wrong. I had to imprison them because I was dependent on beer to keep my other pawns happy.