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Random event to get them.
Yes they are random.
I have yet to see anything, from malaria to the flu, spreading from one to another.
Gut worms, I believe, don't act like most diseases in that they don't have an immunity factor. They'll just go away by themselves eventually.
let them work normally.
they will get treatment autoamtically every time.
if you see they get exhausted, tired, hungry or bad mood cause of the desease, just give them more freetime/sleeptime in the restrict tab.
only if they have flu/malaria i force themm all the time in the beds.
It's just one of those things that having a huge food supply protects against.
But Fibrous Mechanites and Sensory Mechanites will go away by themselves eventually (random timeframe), with or without treatment.
UPD. As I'm remember - mechanites boosting manipulation skill. And it's affecting a lot of stuff - like operations, butchering profit and so on.
And yeah, if they are suffering a lot of pain, start thinking about giving them some drugs to cope with it, like Smokeleaf (probably bad with Gut Worms as Joints increase hunger too) or one of the psychoid drugs.